New
PTD-DBM
97,35 €
FOR PRECLINICAL RESEARCH USE ONLY — NOT APPROVED FOR HUMAN USE.
- Hair follicle regeneration through activation of the Wnt signaling pathway.
- Prevention of hair follicle miniaturization.
- Wound-induced capillary neogenesis.
- Topical administration using a noninvasive approach.
- Synergy with minoxidil and finasteride in combination regimens.
Description
PTD-DBM
Hair Growth
MECHANISM OF ACTION
A cell-penetrating peptide fused to the Dishevelled-binding motif (DBM). It disrupts the CXXC5-Dvl interaction, a negative feedback loop that suppresses Wnt/β-catenin signaling. The resulting activation of the Wnt pathway stimulates hair follicle stem cells in the bulge region, initiating entry into the anagen phase and hair regrowth.
KEY BENEFITS
- Hair follicle regeneration through activation of the Wnt signaling pathway.
- Prevention of hair follicle miniaturization.
- Wound-induced capillary neogenesis.
- Topical administration using a noninvasive approach.
- Synergy with minoxidil and finasteride in combination regimens.
SIDE EFFECTS AND SAFETY
No significant adverse events have been reported in clinical trials. Topical use: mild scalp irritation.
RESEARCH AND CLINICAL NOTES
Kwack et al. (2019): PTD-DBM + valproic acid induced hair regrowth in a model of androgenetic alopecia, with a 28-fold increase in hair follicle count. Activation of the Wnt pathway was confirmed by nuclear translocation of β-catenin.
TARGET PROFILE:
Hair restoration protocols, dermatology, and alopecia management programs.
Additional information
| Weight | ,26 kg |
|---|
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