New
PNC-27
59,99 €
FOR PRECLINICAL RESEARCH USE ONLY — NOT APPROVED FOR HUMAN USE.
- Selective destruction of cancer cells without harming normal cells.
- Activity against breast, ovarian, cervical, and pancreatic cancer cell lines.
- A novel mechanism that differs from conventional chemotherapy.
- Potential to circumvent resistance mechanisms.
Description
PNC-27
Cancer Research
MECHANISM OF ACTION
A 32-residue chimeric p53-penetratin peptide. HDM-2-binding domain, residues 12–26 of p53, fused to a cell-penetrating penetratin sequence. It selectively binds to HDM-2 overexpressed on cancer cell membranes—which is not expressed on normal cell surfaces—promoting the formation of pores in the membrane and the selective necrosis of tumor cells.
KEY BENEFITS
- Selective destruction of cancer cells without harming normal cells.
- Activity against breast, ovarian, cervical, and pancreatic cancer cell lines.
- A novel mechanism that differs from conventional chemotherapy.
- Potential to circumvent resistance mechanisms.
SIDE EFFECTS AND SAFETY
Currently in the research phase only. There is no established human safety profile.
RESEARCH AND CLINICAL NOTES
Bowne et al. (2008): PNC-27 destroyed 100% of breast cancer cells and more than 99% of pancreatic cancer cells in vitro within 1 hour. Selectivity confirmed for tumor cells expressing HDM-2. Phase I in the planning stage.
TARGET PROFILE:
Research protocols focused on oncology and complementary integrative oncology programs.
Additional information
| Weight | ,26 kg |
|---|
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