{"id":38368,"date":"2026-07-09T21:54:05","date_gmt":"2026-07-09T21:54:05","guid":{"rendered":"https:\/\/selmiswiss.com\/?post_type=product&#038;p=38368"},"modified":"2026-07-09T22:10:57","modified_gmt":"2026-07-09T22:10:57","slug":"pnc-27-2","status":"publish","type":"product","link":"https:\/\/selmiswiss.com\/en\/product\/pnc-27-2\/","title":{"rendered":"PNC-27"},"content":{"rendered":"<div class=\"selmi-peptide-sheet\">\n<div class=\"selmi-peptide-header\">\n<div class=\"selmi-peptide-title\">PNC-27<\/div>\n<div class=\"selmi-peptide-category\">Cancer Research<\/div>\n<\/p><\/div>\n<div class=\"selmi-peptide-grid selmi-peptide-grid-top\">\n<section class=\"selmi-peptide-main\">\n<div class=\"selmi-peptide-section\">\n<h3>MECHANISM OF ACTION<\/h3>\n<p>A 32-residue chimeric p53-penetratin peptide. HDM-2-binding domain, residues 12\u201326 of p53, fused to a cell-penetrating penetratin sequence. It selectively binds to HDM-2 overexpressed on cancer cell membranes\u2014which is not expressed on normal cell surfaces\u2014promoting the formation of pores in the membrane and the selective necrosis of tumor cells.  <\/p>\n<\/p><\/div>\n<div class=\"selmi-peptide-section\">\n<h3>KEY BENEFITS<\/h3>\n<ul>\n<li>Selective destruction of cancer cells without harming normal cells.<\/li>\n<li>Activity against breast, ovarian, cervical, and pancreatic cancer cell lines.<\/li>\n<li>A novel mechanism that differs from conventional chemotherapy.<\/li>\n<li>Potential to circumvent resistance mechanisms.<\/li>\n<\/ul><\/div>\n<\/section>\n<aside class=\"selmi-peptide-dosing\">\n<h3>THE RESULTS DESCRIBED WERE OBTAINED BY FOLLOWING THE DOSAGE AND PROTOCOL SET FORTH BELOW<\/h3>\n<h4>1 mg\/day subcutaneous<\/h4>\n<p><strong>Vial size:<\/strong><br \/>5 mg<\/p>\n<p><strong>Frequency:<\/strong><br \/>Once a day<\/p>\n<p><strong>IU \/ Dose:<\/strong><br \/>40 IU<\/p>\n<p><strong>Reconstitution:<\/strong><br \/>Reconstitute with 2 mL of bacteriostatic water. 40 IU = 1 mg. <\/p>\n<p><strong>Series:<\/strong><br \/>Experimental research protocol. Not intended for clinical use. <\/p>\n<\/aside><\/div>\n<div class=\"selmi-peptide-grid selmi-peptide-grid-info\">\n<section class=\"selmi-peptide-box\">\n<h3>SIDE EFFECTS AND SAFETY<\/h3>\n<p>Currently in the research phase only. There is no established human safety profile. <\/p>\n<\/section>\n<section class=\"selmi-peptide-box selmi-peptide-box-alt\">\n<h3>RESEARCH AND CLINICAL NOTES<\/h3>\n<p>Bowne et al. (2008): PNC-27 destroyed 100% of breast cancer cells and more than 99% of pancreatic cancer cells in vitro within 1 hour. Selectivity confirmed for tumor cells expressing HDM-2. Phase I in the planning stage.   <\/p>\n<\/section><\/div>\n<section class=\"selmi-peptide-profile\">\n<h3>TARGET PROFILE:<\/h3>\n<p><em>Research protocols focused on oncology and complementary integrative oncology programs.<\/em><\/p>\n<\/section>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<div class=\"selmi-div-disclaimer\"><span class=\"selmi-disclaimer-text\">FOR PRECLINICAL RESEARCH USE ONLY \u2014 NOT APPROVED FOR HUMAN USE.<\/span><\/div>\n<ul>\n<li>Selective destruction of cancer cells without harming normal cells.<\/li>\n<li>Activity against breast, ovarian, cervical, and pancreatic cancer cell lines.<\/li>\n<li>A novel mechanism that differs from conventional chemotherapy.<\/li>\n<li>Potential to circumvent resistance mechanisms.<\/li>\n<\/ul>\n","protected":false},"featured_media":38374,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[1113],"product_tag":[1101],"class_list":["post-38368","product","type-product","status-publish","has-post-thumbnail","product_cat-healing-tissue-repair-peptides","product_tag-peptides","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"acf":[],"_links":{"self":[{"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product\/38368","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/comments?post=38368"}],"version-history":[{"count":2,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product\/38368\/revisions"}],"predecessor-version":[{"id":38380,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product\/38368\/revisions\/38380"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/media\/38374"}],"wp:attachment":[{"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/media?parent=38368"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product_brand?post=38368"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product_cat?post=38368"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product_tag?post=38368"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}