{"id":38352,"date":"2026-07-09T21:29:19","date_gmt":"2026-07-09T21:29:19","guid":{"rendered":"https:\/\/selmiswiss.com\/?post_type=product&#038;p=38352"},"modified":"2026-07-09T21:48:13","modified_gmt":"2026-07-09T21:48:13","slug":"ptd-dbm","status":"publish","type":"product","link":"https:\/\/selmiswiss.com\/en\/product\/ptd-dbm\/","title":{"rendered":"PTD-DBM"},"content":{"rendered":"<div class=\"selmi-peptide-sheet\">\n<div class=\"selmi-peptide-header\">\n<div class=\"selmi-peptide-title\">PTD-DBM<\/div>\n<div class=\"selmi-peptide-category\">Hair Growth<\/div>\n<\/p><\/div>\n<div class=\"selmi-peptide-grid selmi-peptide-grid-top\">\n<section class=\"selmi-peptide-main\">\n<div class=\"selmi-peptide-section\">\n<h3>MECHANISM OF ACTION<\/h3>\n<p>A cell-penetrating peptide fused to the Dishevelled-binding motif (DBM). It disrupts the CXXC5-Dvl interaction, a negative feedback loop that suppresses Wnt\/\u03b2-catenin signaling. The resulting activation of the Wnt pathway stimulates hair follicle stem cells in the bulge region, initiating entry into the anagen phase and hair regrowth.  <\/p>\n<\/p><\/div>\n<div class=\"selmi-peptide-section\">\n<h3>KEY BENEFITS<\/h3>\n<ul>\n<li>Hair follicle regeneration through activation of the Wnt signaling pathway.<\/li>\n<li>Prevention of hair follicle miniaturization.<\/li>\n<li>Wound-induced capillary neogenesis.<\/li>\n<li>Topical administration using a noninvasive approach.<\/li>\n<li>Synergy with minoxidil and finasteride in combination regimens.<\/li>\n<\/ul><\/div>\n<\/section>\n<aside class=\"selmi-peptide-dosing\">\n<h3>THE RESULTS DESCRIBED WERE OBTAINED BY FOLLOWING THE DOSAGE AND PROTOCOL SET FORTH BELOW<\/h3>\n<h4>0.5 mg\/day topically or subcutaneously<\/h4>\n<p><strong>Vial size:<\/strong><br \/>5 mg<\/p>\n<p><strong>Frequency:<\/strong><br \/>Once a day<\/p>\n<p><strong>IU \/ Dose:<\/strong><br \/>20 IU<\/p>\n<p><strong>Reconstitution:<\/strong><br \/>Reconstitute with 2 mL of bacteriostatic water. 20 IU = 0.5 mg. Topical application to the scalp is preferred.  <\/p>\n<p><strong>Course:<\/strong><br \/>12\u201324 weeks. Consistent daily application is required. <\/p>\n<\/aside><\/div>\n<div class=\"selmi-peptide-grid selmi-peptide-grid-info\">\n<section class=\"selmi-peptide-box\">\n<h3>SIDE EFFECTS AND SAFETY<\/h3>\n<p>No significant adverse events have been reported in clinical trials. Topical use: mild scalp irritation. <\/p>\n<\/section>\n<section class=\"selmi-peptide-box selmi-peptide-box-alt\">\n<h3>RESEARCH AND CLINICAL NOTES<\/h3>\n<p>Kwack et al. (2019): PTD-DBM + valproic acid induced hair regrowth in a model of androgenetic alopecia, with a 28-fold increase in hair follicle count. Activation of the Wnt pathway was confirmed by nuclear translocation of \u03b2-catenin.  <\/p>\n<\/section><\/div>\n<section class=\"selmi-peptide-profile\">\n<h3>TARGET PROFILE:<\/h3>\n<p><em>Hair restoration protocols, dermatology, and alopecia management programs.<\/em><\/p>\n<\/section>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<div class=\"selmi-div-disclaimer\"><span class=\"selmi-disclaimer-text\">FOR PRECLINICAL RESEARCH USE ONLY \u2014 NOT APPROVED FOR HUMAN USE.<\/span><\/div>\n<ul>\n<li>Hair follicle regeneration through activation of the Wnt signaling pathway.<\/li>\n<li>Prevention of hair follicle miniaturization.<\/li>\n<li>Wound-induced capillary neogenesis.<\/li>\n<li>Topical administration using a noninvasive approach.<\/li>\n<li>Synergy with minoxidil and finasteride in combination regimens.<\/li>\n<\/ul>\n","protected":false},"featured_media":38358,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[1116],"product_tag":[1101],"class_list":["post-38352","product","type-product","status-publish","has-post-thumbnail","product_cat-longevity-anti-aging-peptides","product_tag-peptides","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"acf":[],"_links":{"self":[{"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product\/38352","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/comments?post=38352"}],"version-history":[{"count":1,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product\/38352\/revisions"}],"predecessor-version":[{"id":38362,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product\/38352\/revisions\/38362"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/media\/38358"}],"wp:attachment":[{"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/media?parent=38352"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product_brand?post=38352"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product_cat?post=38352"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product_tag?post=38352"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}