{"id":38277,"date":"2026-07-08T21:56:48","date_gmt":"2026-07-08T21:56:48","guid":{"rendered":"https:\/\/selmiswiss.com\/?post_type=product&#038;p=38277"},"modified":"2026-07-08T22:01:28","modified_gmt":"2026-07-08T22:01:28","slug":"pt-141","status":"publish","type":"product","link":"https:\/\/selmiswiss.com\/en\/product\/pt-141\/","title":{"rendered":"PT-141"},"content":{"rendered":"<div class=\"selmi-peptide-sheet\">\n<div class=\"selmi-peptide-header\">\n<div class=\"selmi-peptide-title\">PT-141 (Bremelanotide)<\/div>\n<div class=\"selmi-peptide-category\">Sexual Health<\/div>\n<\/p><\/div>\n<div class=\"selmi-peptide-grid selmi-peptide-grid-top\">\n<section class=\"selmi-peptide-main\">\n<div class=\"selmi-peptide-section\">\n<h3>MECHANISM OF ACTION<\/h3>\n<p>Synthetic cyclic heptapeptide derived from MT-2, with an acetylated N-terminal Nle4 and a cyclic lactam at positions 4\u201310. Selective agonist of MC3R and MC4R. Activation of MC4R in the paraventricular nucleus and medial preoptic area promotes the release of dopamine, increasing sexual motivation and arousal. This mechanism is entirely centered on the central nervous system, unlike vascular treatments for erectile dysfunction.   <\/p>\n<\/p><\/div>\n<div class=\"selmi-peptide-section\">\n<h3>KEY BENEFITS<\/h3>\n<ul>\n<li>Improved sexual desire in men and women.<\/li>\n<li>Improvement of erectile function via the central nervous system.<\/li>\n<li>Approved by the FDA for HSDD in premenopausal women as Vyleesi.<\/li>\n<li>Effective in patients who do not respond to PDE5 inhibitors.<\/li>\n<li>It can be used as needed, 45\u201390 minutes before the activity.<\/li>\n<\/ul><\/div>\n<\/section>\n<aside class=\"selmi-peptide-dosing\">\n<h3>THE RESULTS DESCRIBED WERE OBTAINED BY FOLLOWING THE DOSAGE AND PROTOCOL SET FORTH BELOW<\/h3>\n<h4>1.75 mg subcutaneously 45 minutes before the activity<\/h4>\n<p><strong>Vial size:<\/strong><br \/>10 mg<\/p>\n<p><strong>Frequency:<\/strong><br \/>As needed, up to once every 24 hours<\/p>\n<p><strong>IU \/ Dose:<\/strong><br \/>35 IU<\/p>\n<p><strong>Reconstitution:<\/strong><br \/>Reconstitute with 2 mL of bacteriostatic water. 35 IU = 1.75 mg. <\/p>\n<p><strong>Cycle:<\/strong><br \/>Use as needed. Not intended for daily use. <\/p>\n<\/aside><\/div>\n<div class=\"selmi-peptide-grid selmi-peptide-grid-info\">\n<section class=\"selmi-peptide-box\">\n<h3>SIDE EFFECTS AND SAFETY<\/h3>\n<p>Nausea is the most common side effect; pretreatment with ondansetron may be considered if necessary. Flushing, headache, and transient hypotension. Hyperpigmentation with repeated use. Contraindicated in patients at high cardiovascular risk.   <\/p>\n<\/section>\n<section class=\"selmi-peptide-box selmi-peptide-box-alt\">\n<h3>RESEARCH AND CLINICAL NOTES<\/h3>\n<p>Approved by the FDA in June 2019 as Vyleesi for HSDD. Clinical trials in men show a significant improvement in erectile function scores. Mechanism of action entirely focused on the CNS, validated for psychogenic erectile dysfunction and female sexual dysfunction.  <\/p>\n<\/section><\/div>\n<section class=\"selmi-peptide-profile\">\n<h3>TARGET PROFILE:<\/h3>\n<p><em>Protocols for men&#8217;s and women&#8217;s sexual health, urology, and gynecology.<\/em><\/p>\n<\/section>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<div class=\"selmi-div-disclaimer\"><span class=\"selmi-disclaimer-text\">FOR PRECLINICAL RESEARCH USE ONLY \u2014 NOT APPROVED FOR HUMAN USE.<\/span><\/div>\n<ul>\n<li>Improved sexual desire in men and women.<\/li>\n<li>Improvement of erectile function via the central nervous system.<\/li>\n<li>Approved by the FDA for HSDD in premenopausal women as Vyleesi.<\/li>\n<li>Effective in patients who do not respond to PDE5 inhibitors.<\/li>\n<li>It can be used as needed, 45\u201390 minutes before the activity.<\/li>\n<\/ul>\n","protected":false},"featured_media":38283,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[1114],"product_tag":[1101],"class_list":["post-38277","product","type-product","status-publish","has-post-thumbnail","product_cat-hormonal-balance-peptides","product_tag-peptides","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"acf":[],"_links":{"self":[{"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product\/38277","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/comments?post=38277"}],"version-history":[{"count":1,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product\/38277\/revisions"}],"predecessor-version":[{"id":38287,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product\/38277\/revisions\/38287"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/media\/38283"}],"wp:attachment":[{"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/media?parent=38277"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product_brand?post=38277"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product_cat?post=38277"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product_tag?post=38277"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}