{"id":38152,"date":"2026-07-08T19:14:23","date_gmt":"2026-07-08T19:14:23","guid":{"rendered":"https:\/\/selmiswiss.com\/?post_type=product&#038;p=38152"},"modified":"2026-07-08T19:22:45","modified_gmt":"2026-07-08T19:22:45","slug":"kpv","status":"publish","type":"product","link":"https:\/\/selmiswiss.com\/en\/product\/kpv\/","title":{"rendered":"KPV"},"content":{"rendered":"<div class=\"selmi-peptide-sheet\">\n<div class=\"selmi-peptide-header\">\n<div class=\"selmi-peptide-title\">KPV<\/div>\n<div class=\"selmi-peptide-category\">Anti-inflammatory \/ GI \/ Immune<\/div>\n<\/p><\/div>\n<div class=\"selmi-peptide-grid selmi-peptide-grid-top\">\n<section class=\"selmi-peptide-main\">\n<div class=\"selmi-peptide-section\">\n<h3>MECHANISM OF ACTION<\/h3>\n<p>C-terminal tripeptide of \u03b1-MSH (Lys-Pro-Val). It retains the immunomodulatory activity of the original hormone. It directly inhibits the NF-\u03baB and MAPK inflammatory cascades in intestinal epithelial cells. It reduces TNF-\u03b1, IL-1\u03b2, and IL-6. It activates melanocortin receptors in gastrointestinal tissue to promote mucosal repair.    <\/p>\n<\/p><\/div>\n<div class=\"selmi-peptide-section\">\n<h3>KEY BENEFITS<\/h3>\n<ul>\n<li>Powerful anti-inflammatory action in the intestines for IBD, Crohn&#8217;s disease, and colitis.<\/li>\n<li>Restoration of intestinal barrier function in intestinal permeability protocols.<\/li>\n<li>Systemic anti-inflammatory effect without immunosuppression.<\/li>\n<li>Supports healing and reduces skin inflammation.<\/li>\n<li>Oral bioavailability for administration targeted at the gastrointestinal tract.<\/li>\n<li>Safe: extremely low molecular weight and no systemic toxicity.<\/li>\n<\/ul><\/div>\n<\/section>\n<aside class=\"selmi-peptide-dosing\">\n<h3>THE RESULTS DESCRIBED WERE OBTAINED BY FOLLOWING THE DOSAGE AND PROTOCOL SET FORTH BELOW<\/h3>\n<h4>500 mcg\/day subcutaneously \u2014 or oral capsule for GI use<\/h4>\n<p><strong>Vial size:<\/strong><br \/>50 mg<\/p>\n<p><strong>Frequency:<\/strong><br \/>Once a day<\/p>\n<p><strong>IU \/ Dose:<\/strong><br \/>2 IU<\/p>\n<p><strong>Reconstitution:<\/strong><br \/>Reconstitute with 2 mL of bacteriostatic water. 2 IU = 500 mcg. Alternatively: oral capsule formulation for intestinal administration.  <\/p>\n<p><strong>Course:<\/strong><br \/>4\u20138 weeks. Excellent for acute gastrointestinal flare-ups. <\/p>\n<\/aside><\/div>\n<div class=\"selmi-peptide-grid selmi-peptide-grid-info\">\n<section class=\"selmi-peptide-box\">\n<h3>SIDE EFFECTS AND SAFETY<\/h3>\n<p>Very few adverse effects have been reported. Its small size and natural origin contribute to excellent tolerability. <\/p>\n<\/section>\n<section class=\"selmi-peptide-box selmi-peptide-box-alt\">\n<h3>RESEARCH AND CLINICAL NOTES<\/h3>\n<p>Kannengiesser et al. (2008): KPV-loaded nanoparticles significantly reduced colitis in a mouse model. Anti-NF-\u03baB activity was confirmed in human intestinal epithelial cell lines.  <\/p>\n<\/section><\/div>\n<section class=\"selmi-peptide-profile\">\n<h3>TARGET PROFILE:<\/h3>\n<p><em>Specialized practices in gastrointestinal health, IBD management programs, intestinal permeability protocols, and integrative medicine.<\/em><\/p>\n<\/section>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<div class=\"selmi-div-disclaimer\"><span class=\"selmi-disclaimer-text\">FOR PRECLINICAL RESEARCH USE ONLY \u2014 NOT APPROVED FOR HUMAN USE.<\/span><\/div>\n<ul>\n<li>Powerful anti-inflammatory action in the intestines for IBD, Crohn&#8217;s disease, and colitis.<\/li>\n<li>Restoration of intestinal barrier function in intestinal permeability protocols.<\/li>\n<li>Systemic anti-inflammatory effect without immunosuppression.<\/li>\n<li>Supports healing and reduces skin inflammation.<\/li>\n<li>Oral bioavailability for administration targeted at the gastrointestinal tract.<\/li>\n<li>Safe: extremely low molecular weight and no systemic toxicity.<\/li>\n<\/ul>\n","protected":false},"featured_media":38157,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[1113],"product_tag":[1101],"class_list":["post-38152","product","type-product","status-publish","has-post-thumbnail","product_cat-healing-tissue-repair-peptides","product_tag-peptides","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"acf":[],"_links":{"self":[{"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product\/38152","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/comments?post=38152"}],"version-history":[{"count":1,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product\/38152\/revisions"}],"predecessor-version":[{"id":38161,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product\/38152\/revisions\/38161"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/media\/38157"}],"wp:attachment":[{"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/media?parent=38152"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product_brand?post=38152"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product_cat?post=38152"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product_tag?post=38152"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}