{"id":38059,"date":"2026-07-08T15:24:03","date_gmt":"2026-07-08T15:24:03","guid":{"rendered":"https:\/\/selmiswiss.com\/?post_type=product&#038;p=38059"},"modified":"2026-07-08T15:51:56","modified_gmt":"2026-07-08T15:51:56","slug":"nad","status":"publish","type":"product","link":"https:\/\/selmiswiss.com\/en\/product\/nad\/","title":{"rendered":"NAD+"},"content":{"rendered":"<div class=\"selmi-peptide-sheet\">\n<div class=\"selmi-peptide-header\">\n<div class=\"selmi-peptide-title\">NAD+<\/div>\n<div class=\"selmi-peptide-category\">Longevity \/ Energy \/ Cellular Health<\/div>\n<\/p><\/div>\n<div class=\"selmi-peptide-grid selmi-peptide-grid-top\">\n<section class=\"selmi-peptide-main\">\n<div class=\"selmi-peptide-section\">\n<h3>MECHANISM OF ACTION<\/h3>\n<p>Universal cellular cofactor in its oxidized form. It accepts electrons in glycolysis and the TCA cycle, forming NADH, and fuels oxidative phosphorylation. It serves as a substrate for sirtuin deacetylases (SIRT1\u20137), which regulate longevity; PARP, DNA repair enzymes; and CD38\/cADPR, involved in calcium signaling. Its levels decrease by 40\u201350% by middle age.   <\/p>\n<\/p><\/div>\n<div class=\"selmi-peptide-section\">\n<h3>KEY BENEFITS<\/h3>\n<ul>\n<li>Optimization of cellular energy and efficiency in ATP production.<\/li>\n<li>Activation of sirtuins for the epigenetic regulation of longevity.<\/li>\n<li>Repair of DNA damage through PARP activation.<\/li>\n<li>Improved mitochondrial biogenesis.<\/li>\n<li>Cognitive clarity and support for neurological function.<\/li>\n<li>Applications in research on addiction and depression.<\/li>\n<\/ul><\/div>\n<\/section>\n<aside class=\"selmi-peptide-dosing\">\n<h3>THE RESULTS DESCRIBED WERE OBTAINED BY FOLLOWING THE DOSAGE AND PROTOCOL SET FORTH BELOW<\/h3>\n<h4>500 mg\/day IV or subcutaneous<\/h4>\n<p><strong>Vial size:<\/strong><br \/>500 mg<\/p>\n<p><strong>Frequency:<\/strong><br \/>Once a day<\/p>\n<p><strong>IU \/ Dose:<\/strong><br \/>200 IU<\/p>\n<p><strong>Reconstitution:<\/strong><br \/>Reconstitute with 2 mL of bacteriostatic water. 200 IU = 500 mg. IV administration is preferred for greater bioavailability.  <\/p>\n<p><strong>Cycle:<\/strong><br \/>IV: 4-day loading protocol and monthly maintenance. SubQ: continuous. <\/p>\n<\/aside><\/div>\n<div class=\"selmi-peptide-grid selmi-peptide-grid-info\">\n<section class=\"selmi-peptide-box\">\n<h3>SIDE EFFECTS AND SAFETY<\/h3>\n<p>IV: flushing, headache, and nausea if infused too quickly; it should be administered by drip over 2\u20134 hours. SubQ: discomfort at the injection site. Oral forms are largely ineffective; oral precursors such as NMN\/NR are preferred.  <\/p>\n<\/section>\n<section class=\"selmi-peptide-box selmi-peptide-box-alt\">\n<h3>RESEARCH AND CLINICAL NOTES<\/h3>\n<p>Yoshino et al. (NEJM 2021): NMN supplementation increased NAD+ levels and improved muscle insulin sensitivity in postmenopausal women. IV NAD+ is widely used in addiction medicine. Sirtuins have been confirmed as mediators of longevity.   <\/p>\n<\/section><\/div>\n<section class=\"selmi-peptide-profile\">\n<h3>TARGET PROFILE:<\/h3>\n<p><em>Longevity and anti-aging protocols, IV therapy, cognitive performance programs, and addiction recovery medicine.<\/em><\/p>\n<\/section>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<div class=\"selmi-div-disclaimer\"><span class=\"selmi-disclaimer-text\">FOR PRECLINICAL RESEARCH USE ONLY \u2014 NOT APPROVED FOR HUMAN USE.<\/span><\/div>\n<ul>\n<li>Optimization of cellular energy and efficiency in ATP production.<\/li>\n<li>Activation of sirtuins for the epigenetic regulation of longevity.<\/li>\n<li>Repair of DNA damage through PARP activation.<\/li>\n<li>Improved mitochondrial biogenesis.<\/li>\n<li>Cognitive clarity and support for neurological function.<\/li>\n<li>Applications in research on addiction and depression.<\/li>\n<\/ul>\n","protected":false},"featured_media":38069,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[1116],"product_tag":[1101],"class_list":["post-38059","product","type-product","status-publish","has-post-thumbnail","product_cat-longevity-anti-aging-peptides","product_tag-peptides","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"acf":[],"_links":{"self":[{"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product\/38059","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/comments?post=38059"}],"version-history":[{"count":2,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product\/38059\/revisions"}],"predecessor-version":[{"id":38074,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product\/38059\/revisions\/38074"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/media\/38069"}],"wp:attachment":[{"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/media?parent=38059"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product_brand?post=38059"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product_cat?post=38059"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product_tag?post=38059"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}