{"id":37910,"date":"2026-07-07T20:44:57","date_gmt":"2026-07-07T20:44:57","guid":{"rendered":"https:\/\/selmiswiss.com\/?post_type=product&#038;p=37910"},"modified":"2026-07-07T20:58:37","modified_gmt":"2026-07-07T20:58:37","slug":"semaglutide","status":"publish","type":"product","link":"https:\/\/selmiswiss.com\/en\/product\/semaglutide\/","title":{"rendered":"Semaglutide"},"content":{"rendered":"<div class=\"selmi-peptide-sheet\">\n<div class=\"selmi-peptide-header\">\n<div class=\"selmi-peptide-title\">Semaglutide<\/div>\n<div class=\"selmi-peptide-category\">Weight Loss \/ Diabetes \/ Cardiovascular<\/div>\n<\/p><\/div>\n<div class=\"selmi-peptide-grid selmi-peptide-grid-top\">\n<section class=\"selmi-peptide-main\">\n<div class=\"selmi-peptide-section\">\n<h3>MECHANISM OF ACTION<\/h3>\n<p>GLP-1 analog with 94% homology, featuring a C18 diacid fatty acid chain and two Aib substitutions for DPP-4 resistance. It binds to the GLP-1 receptor (GLP-1R), leading to glucose-dependent insulin secretion, glucagon suppression, delayed gastric emptying, and hypothalamic appetite suppression. It has an approximate half-life of 7 days due to binding to albumin. It also reduces neuroinflammation and cardiovascular inflammation.   <\/p>\n<\/p><\/div>\n<div class=\"selmi-peptide-section\">\n<h3>KEY BENEFITS<\/h3>\n<ul>\n<li>Average body weight reduction of 15\u201317% with 2.4 mg per week.<\/li>\n<li>A 1.5\u20132.0% reduction in HbA1c.<\/li>\n<li>A 20% reduction in MACE in the SELECT trial among an obese, non-diabetic population.<\/li>\n<li>Remission of NASH in clinical trials.<\/li>\n<li>Reduced cravings for substances and alcohol, according to emerging data.<\/li>\n<li>Potential cognitive protection in dementia research.<\/li>\n<\/ul><\/div>\n<\/section>\n<aside class=\"selmi-peptide-dosing\">\n<h3>THE RESULTS DESCRIBED WERE OBTAINED BY FOLLOWING THE DOSAGE AND PROTOCOL SET FORTH BELOW<\/h3>\n<h4>0.25 mg weekly \u2192 titrate up to 2.4 mg over 16\u201320 weeks<\/h4>\n<p><strong>Vial size:<\/strong><br \/>3 mg<\/p>\n<p><strong>Frequency:<\/strong><br \/>Once a week<\/p>\n<p><strong>IU \/ Dose:<\/strong><br \/>17 IU = 0.25 mg initial dose<\/p>\n<p><strong>Reconstitution:<\/strong><br \/>Reconstitute with 2 mL of bacteriostatic water. 17 IU = 0.25 mg. Adjust the dose every 4 weeks.  <\/p>\n<p><strong>Course:<\/strong><br \/>Chronic use. The titration protocol is essential for gastrointestinal tolerability. <\/p>\n<\/aside><\/div>\n<div class=\"selmi-peptide-grid selmi-peptide-grid-info\">\n<section class=\"selmi-peptide-box\">\n<h3>SIDE EFFECTS AND SAFETY<\/h3>\n<p>Nausea, vomiting, and diarrhea\u2014the most common side effects\u2014usually resolve with dose titration. Rare: pancreatitis, gastroparesis, and C-cell thyroid tumors as class warnings. Rapid weight loss can reduce muscle mass; combine with resistance exercise.  <\/p>\n<\/section>\n<section class=\"selmi-peptide-box selmi-peptide-box-alt\">\n<h3>RESEARCH AND CLINICAL NOTES<\/h3>\n<p>SELECT Trial (2023, NEJM): 20% reduction in MACE in 17,604 overweight subjects without diabetes. STEP Trials: 15\u201317% reduction in body weight. The most commercially successful peptide in history.  <\/p>\n<\/section><\/div>\n<section class=\"selmi-peptide-profile\">\n<h3>TARGET PROFILE:<\/h3>\n<p><em>Clinical practice in metabolism, cardiovascular medicine, and weight loss.<\/em><\/p>\n<\/section>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<div class=\"selmi-div-disclaimer\"><span class=\"selmi-disclaimer-text\">FOR PRECLINICAL RESEARCH USE ONLY \u2014 NOT APPROVED FOR HUMAN USE.<\/span><\/div>\n<ul>\n<li>Average body weight reduction of 15\u201317% with 2.4 mg per week.<\/li>\n<li>A 1.5\u20132.0% reduction in HbA1c.<\/li>\n<li>A 20% reduction in MACE in the SELECT trial among an obese, non-diabetic population.<\/li>\n<li>Remission of NASH in clinical trials.<\/li>\n<li>Reduced cravings for substances and alcohol, according to emerging data.<\/li>\n<li>Potential cognitive protection in dementia research.<\/li>\n<\/ul>\n","protected":false},"featured_media":37945,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[1115],"product_tag":[1101],"class_list":["post-37910","product","type-product","status-publish","has-post-thumbnail","product_cat-obesity-metabolism-peptides","product_tag-peptides","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"acf":[],"_links":{"self":[{"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product\/37910","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/comments?post=37910"}],"version-history":[{"count":2,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product\/37910\/revisions"}],"predecessor-version":[{"id":37925,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product\/37910\/revisions\/37925"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/media\/37945"}],"wp:attachment":[{"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/media?parent=37910"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product_brand?post=37910"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product_cat?post=37910"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/selmiswiss.com\/en\/wp-json\/wp\/v2\/product_tag?post=37910"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}